When Is The 2025 Kentucky Derby Start Time. The 151st running of the kentucky derby will take place on saturday, may 3rd, 2025, with the main event usually taking place between 6:00 and 7:00 pm est. The 2025 kentucky derby will take place on saturday, may 3rd, with the horses leaving the gate at 6:57 p.m.

When is the kentucky derby? The 2025 kentucky derby will take place on saturday, may 3rd, with the horses leaving the gate at 6:57 p.m.